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Limitations of useThe safety and effectiveness of colchicine capsules for acute treatment of gout flares during prophylaxis has not been studied.
This medication is also used to prevent attacks of pain in the abdomenchestor joints caused by a certain inherited diseasefamilial Mediterranean feverIt is thought to work by decreasing your body’s production of a certain proteinamyloid Athat builds up in people with familial Mediterranean fever.
Carcinogenicity studies of colchicine have not been conductedDue to the potential for colchicine to produce aneuploid cellscells with an unequal number of chromosomescolchicine presents a theoretical increased risk of malignancy.
The magnitude of interactions with strong and moderate CYP3A4 inhibitors as well as with P-gp inhibitors from performed in vivo studies is summarised in the table below:
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colchicine has been reported to adversely affect spermatogenesis in animals.