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Tranexamic acid passes through the placentaThe concentration in cord blood after an intravenous injection of 10 mg per kg to pregnant women is about 30 mg per literas high as in the maternal bloodTranexamic acid diffuses rapidly into joint fluid and the synovial membraneIn the joint fluidthe same concentration is obtained as in the serumThe biological half-life of tranexamic acid in the joint fluid is about three hours.

Thromboembolic eventse.gdeep vein thrombosispulmonary embolismcerebral thrombosisacute renal cortical necrosisand central retinal artery and vein obstructionhave been rarely reported in patients receiving tranexamic acid for indications other than hemorrhage prevention in patients with hemophiliaConvulsionchromatopsiaand visual impairment have also been reportedHoweverdue to the spontaneous nature of the reporting of medical events and the lack of controlsthe actual incidence and causal relationship of drug and event cannot be determined.

WARNING/CAUTIONEven though it may be raresome people may have very bad and sometimes deadly side effects when taking a drugTell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Cases of overdosage of Cyklokapron have been reportedBased on these reportssymptoms of overdosage may be gastrointestinale.gnauseavomitingdiarrheahypotensivee.gorthostatic symptomsthromboembolice.garterialvenousembolicneurologice.gvisual impairmentconvulsionsheadachemental status changesmyoclonusand rash.

Long-term prophylaxis1000-1500 mg PO q8-12hrreduce dose to 500 mg/dose PO qDay or q12hr when frequency of attacks reduces.

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