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Adultsadminister 15 mg/kg by mouth once dailyDose adjustments are made based on patient’s blood countsPatient’s blood counts are monitored every two weeksIf the blood counts are in anacceptablerangethe dose may be increased by 5 mg/kg/day every 12 weeks until a maximum tolerated dosehighest dose that does not produce toxic blood countsor 35 mg/kg/day is reached.

Fatigue is very common during cancer treatment and is an overwhelming feeling of exhaustion that is not usually relieved by restWhile on cancer treatmentand for a period afteryou may need to adjust your schedule to manage fatiguePlan times to rest during the day and conserve energy for more important activitiesExercise can help combat fatiguea simple daily walk with a friend can helpTalk to your healthcare team for helpful tips on dealing with this side effect.

Tell your doctor if you are pregnant or plan to become pregnantYou should not become pregnant while using hydroxyureaHydroxyurea may harm an unborn babyMen with female partners of childbearing age should ask about reliable forms of birth control while using this medication and for 1 year after stopping treatmentWomen of childbearing age should ask about reliable forms of birth control while using this medication and for 6 months after stopping treatmentIf you or your partner becomes pregnant or may be pregnanttell your doctor right away.

Since this drug can be absorbed through the skin and lungswomen who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets/capsules.

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in vitro studies utilizing chinese hamster cells suggest that hydrea 1 is lethal to normally radioresistant s-stage cells, and 2 holds other cells of the cell cycle in the g1 or pre-dna synthesis stage where they are most susceptible to the effects of irradiation.