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Two hundred sixty-eight hypertensive patients aged 6 to 17 years were randomized first to norvasc 2.

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Worsening of angina and acute myocardial infarctionMIcan develop after dose is started or increasedparticularly with severe obstructive CAD.

Electrophysiologic EffectsNorvasc does not change sinoatrial nodal function or atrioventricular conduction in intact animals or manIn patients with chronic stable anginaintravenous administration of 10 mg did not significantly alter A-H and H-V conduction and sinus node recovery time after pacingSimilar results were obtained in patients receiving Norvasc and concomitant beta-blockersIn clinical studies in which Norvasc was administered in combination with beta-blockers to patients with either hypertension or anginano adverse effects on electrocardiographic parameters were observedIn clinical trials with angina patients aloneNorvasc therapy did not alter electrocardiographic intervals or produce higher degrees of AV blocks.

The precise mechanisms by which amlodipine relieves angina have not been fully delineatedbut are thought to include the following:

Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Norvascparticularly in patients with severe obstructive coronary artery disease.

6 to 17 yearsMaintenance dose2.5 to 5 mg orally once a dayMaximum dose5 mg/day.

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