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The development of bupropion resulted from a targeted program designed to produce an antidepressant with a unique pharmacologic profile that offered safety and tolerability advantages over existing agents1 Bupropion’s safety and efficacy were established in several clinical trialsand with U.SFood and Drug AdministrationFDAapproval in 1989it was introduced as a treatment for major depressive disorderThe formulation was an IR tabletwhich required thrice-daily dosingAlthough clinically effectivethe dosing schedule was inconvenient for patientsBecause of this inconvenienceas well as evidence implicating a relationship between peak plasma concentrations and some adverse eventsdevelopment of an SR formulation was initiated45.

Among antidepressantsbupropion may be associated with the lowest incidence of sexual dysfunctioni.eimpotenceabnormal ejaculationchanges in libidoRef]

15 Years of Clinical Experience With Bupropion HClFrom Bupropion to Bupropion SR to Bupropion XL.

Blurred visiontunnel visioneye pain or swellingor seeing halos around lights;

Postmarketing reportsAkinesiaaphasiacomaextrapyramidal syndromehypokinesianeuropathyneuralgiaunmasking tardive dyskinesiaRef]

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