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Since the mechanisms of these reactions are not fully understoodit seems prudentin generalto avoid this combination of ELDEPRYL and tricyclic antidepressants as well as ELDEPRYL and selective serotonin re-uptake inhibitorsAt least 14 days should elapse between discontinuation of ELDEPRYL and initiation of treatment with a tricyclic antidepressant or selective serotonin re-uptake inhibitorsBecause of the long half-lives of fluoxetine and its active metaboliteat least five weeksperhaps longerespecially if fluoxetine has been prescribed chronically and/or at higher dosesshould elapse between discontinuation of fluoxetine and initiation of treatment with ELDEPRYL.

Concomitant administration of amantadine and anticholinergic drugs can lead to an increased occurrence of side-effects.

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