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MAO-B inhibition may be useful in this setting becauseby blocking the catabolism of dopamineit would increase the net amount of dopamine availablei.eit would increase the pool of dopamineWhether or not this mechanism or an alternative one actually accounts for the observed beneficial effects of adjunctive selegiline is unknown.
Since the mechanisms of these reactions are not fully understoodit seems prudentin generalto avoid this combination of ELDEPRYL and tricyclic antidepressants as well as ELDEPRYL and selective serotonin re-uptake inhibitorsAt least 14 days should elapse between discontinuation of ELDEPRYL and initiation of treatment with a tricyclic antidepressant or selective serotonin re-uptake inhibitorsBecause of the long half-lives of fluoxetine and its active metaboliteat least five weeksperhaps longerespecially if fluoxetine has been prescribed chronically and/or at higher dosesshould elapse between discontinuation of fluoxetine and initiation of treatment with ELDEPRYL.
Concomitant administration of amantadine and anticholinergic drugs can lead to an increased occurrence of side-effects.
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