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Concomitant use of certain drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition see warnings and precautions 5.

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LovastatinMevacorpravastatinPravacholsimvastatinZocorfluvastatinLescolrosuvastatinCrestorand atorvastatinLipitorAll these increase the risk of a condition called rhabdomyolysismuscle injurythat when severe can lead to kidney damage and even deathRhabdomyolysis may occur as early as three weeks or several months after starting combination therapyThe benefit of combining gemfibrozil with statins does not outweigh the risk of rhabdomyolysis.

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