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Porphyria danazol can induce ala synthetase activity and hence porphyrin metabolism.

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Fluid retention may explain the occasional reports of carpal tunnel syndromeDanazol may also provoke migraine.

Hepatic dysfunctionas evidenced by reversible elevated serum enzymes and/or jaundicehas been reported in patients receiving a daily dosage of Danazol of 400 mg or moreIt is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observationSerious hepatic toxicity including cholestatic jaundicepeliosis hepatisand hepatic adenoma have been reportedSee WARNINGS and PRECAUTIONS

BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

There is epidemiological and toxicological evidence of hazard in human pregnancyDanazol is known to be associated with the risk of virilisation to the female foetus if administered during human pregnancyDanazol should not be used during pregnancyWomen of childbearing age should be advised to use an effectivenon-hormonalmethod of contraceptionIf the patient conceives during therapyDanazol should be stopped.

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