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Contraindications and precautions Contraindicated in patients hypersensitive to drug and patients with anuriahepatic comaor severe electrolyte depletionContraindicated if increased azotemiaoliguriaor progressive renal disease occur during therapyUse cautiously in pregnant womenpatients with sulfa allergyand in those with hepatic cirrhosis.

Choe et al2015High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neuronsAutophagy 85 549 PMID25619659.

Loop diuretic that inhibits the Na2ClKNKCCsymporterAlso acts as a non-competitive antagonist at GABA A receptors with.

Individual intolerance to the active ingredient or other components of the medication dehydration hypokalemia and/or hyponatremialow potassium and/or sodium content in the bloodfailure of renal function comatose or precomatose condition due to hepatic encephalopathy pregnancy breastfeeding.

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