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Those experiencing lethargy at the beginning of treatment can also take paxil with positive results because paxil does not impair psychomotor function.

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Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapybut particularly with concomitant use of other serotonergic drugs and drugs that impair the metabolism of serotoninSigns and symptoms associated with serotonin syndrome or neuroleptic malignant syndrome included agitationconfusiondiaphoresisdiarrheafeverhypertensionrigidityand tachycardiaand were in some cases associated with concomitant use of serotonergic drugsRef]

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