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Patients with signs and symptoms of hepatitis should discontinue viramune and seek medical evaluation immediately.

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Nevirapine was approved by the FDA in 1996 for use in combination with nucleoside analogues in adults with HIV infectionApproval was based on studies showing that the combination of nevirapine with zidovudinedidanosine was more effective in increasing CD4 T-lymphocyte counts and decreasing HIV viral load than a regimen of zidovudinedidanosine alone1Nevirapine was approved for pediatric use in 1998Extended-release formulations for adults and for pediatric patients were approved in 2011 and 2012respectively.

An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapySuch changes may in part be linked to disease control and life styleFor lipidsthere is in some cases evidence for a treatment effectwhile for weight gain there is no strong evidence relating this to any particular treatmentFor monitoring of blood lipids and glucose reference is made to established HIV treatment guidelinesLipid disorders should be managed as clinically appropriate.

A clinically not relevant increase in the apparent clearance of nevirapineby 9compared to historical data was reported.

Methadone-maintained patients beginning Viramune therapy should be monitored for evidence of withdrawal and methadone dose should be adjusted accordingly.

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