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Amoxicillin, clarithromycin, lansoprazole major use caution when administering high-dose methotrexate to patients receiving proton pump inhibitors ppis , a temporary withdrawal of the ppi should be considered in some patients receiving high-dose methotrexate.

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Treatments may occur at 456711121516293044and 45 weeks after surgery.

Get emergency medical help if you have signs of an allergic reaction to methotrexatehivesdifficult breathingswelling in your face or throator a severe skin reactionfeversore throatburning in your eyesskin painred or purple skin rash that spreads and causes blistering and peeling

Methotrexate is a strong medicationThe dosage and how often you take this medication are based on your medical condition and response to treatmentThere are many different dosing schedules for this medicationespecially for cancer treatmentTaking this medication the wrong way may cause serious side effectsincluding deathThereforeit is very important that you follow your doctor’s instructions carefullyTake this medication by mouth as directed by your doctor.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney diseaselung diseasesuch as pulmonary fibrosisalcohol usesuppressed immune systemblood cell/bone marrow disordersstomach/intestinal diseasessuch as peptic ulcerulcerative colitisany active infectionincluding chickenpox or recent exposure to itfolic acid deficiency.

100 mg/m2 over 1 hour followed by a 35 hour infusion delivering 900 mg/m2/day.

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in a small n 30 combination study of arava with methotrexate, a 2- to 3-fold elevation in liver enzymes was seen in 5 of 30 patients.