Table 1 lists adverse reactions seen at an incidence of 2 in either exelon patch-treated group in study 1 and for which the rate of occurrence was greater for patients treated with that dose of exelon patch than for those treated with placebo.
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After a 6-mg dose of rivastigmineanticholinesterase activity is present in cerebrospinal fluidCSFfor about 10 hourswith a maximum inhibition of about 605 hours after dosing.
Although not observed in clinical trials of rivastigminedrugs that increase cholinergic activity may cause urinary obstruction.
The most common adverse reactionsdefined as those occurring at a frequency of at least 5and twice the placebo rateare largely predicted by EXELON’s cholinergic effectsThese include nauseavomitingtremoranorexiaand dizziness.
Rivastigmine is weakly bound to plasma proteinsapproximately 40over the therapeutic rangeIt readily crosses the blood-brain barrierreaching CSF peak concentrations in 1.4 to 2.6 hoursIt has an apparent volume of distribution in the range of 1.8 to 2.7 L/kg.
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