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You may be more likely to have hyperglycemiahigh blood sugarif you are taking repaglinide with other drugs that raise blood sugarsuch as:

Prandin has no direct influence on the ability to drive and use machines but may cause hypoglycaemia.

Avoid drinking alcoholIt lowers blood sugar and may interfere with your diabetes treatment.

In vitro data indicate that repaglinide is metabolised predominantly by CYP2C8but also by CYP3A4Clinical data in healthy volunteers support CYP2C8 as being the most important enzyme involved in repaglinide metabolism with CYP3A4 playing a minor rolebut the relative contribution of CYP3A4 can be increased if CYP2C8 is inhibitedConsequently metabolismand by that clearance of repaglinidemay be altered by substances which influence these cytochrome P-450 enzymes via inhibition or inductionSpecial care should be taken when inhibitors of both CYP2C8 and 3A4 are co-administered simultaneously with repaglinide.

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