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In combination with docetaxelthe recommended dose of XELODA is 1250 mg/m 2 twice daily for 2 weeks followed by a 1-week rest periodcombined with docetaxel at 75 mg/m 2 as a 1-hour intravenous infusion every 3 weeksPre-medicationaccording to the docetaxel labelingshould be started prior to docetaxel administration for patients receiving the XELODA plus docetaxel combinationTable 1 displays the total daily dose of XELODA by body surface area and the number of tablets to be taken at each dose.

Patients with moderatecreatinine clearance30 to 50 mL/minand severecreatinine clearance.

Distributed byGenentech USAIncA Member of the Roche Group1 DNA WaySouth San FranciscoCA 94080-4990RevisedMar 2015.

XELODA is contraindicated in patients with severe renal impairmentcreatinine clearance below 30 mL/minCockroft and Gaultsee Use In Specific Populations and CLINICAL PHARMACOLOGY

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