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Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemia and decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4 and 5.1

Concomitant administration of ACE inhibitors and lovastatin increases the risk of hyperkalaemia.

CommentsMay increase dose every 2 to 3 weeksIf blood pressure is controlled with monotherapy hydrochlorothiazide 25 mg per daybut significant potassium loss occursthen similar or greater blood pressure control without electrolyte disturbance may be achieved with hydrochlorothiazide 12.5 mg-lisinopril 10 mg orally once a day.

Lisinopril is in an ACE inhibitorACE stands for angiotensin converting enzymeLisinopril lowers blood pressure and also relieves symptoms of fluid retention.

The usual dosage is one tabletadministered once dailyAs with all other medication taken once dailyZestoretic should be taken at approximately the same time each day.

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