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2Summaries for patientsMuscle abnormalities in four patients taking statins to treat unfavorable cholesterol levelsAnn Intern Med 1372002I45.

40Galatti LPolimeni GSalvo FRomani MSessa ASpina EShort-term memory loss associated with rosuvastatinPharmacotherapy 2620061190-2.

The recommended dose range of simvastatin is 10 mg to 40 mgand it is administered once daily in the evening with or without foodTherapy usually is initiated with 10 or 20 mg dailybut individuals who have a high risk of heart disease can be started on 40 mg dailySimvastatin 80 mg is restricted to patients who have been taking simvastatin 80 mg chronicallyfor examplefor 12 months or morewithout evidence of muscle toxicity because the 80 mg dose is associated with increased risk of muscle toxicityincluding rhabdomyolysisPatients who are currently tolerating the 80 mg dose of simvastatin who need to start an interacting drug that should not be taken with simvastatin or is associated with a dose cap for simvastatin should be switched to an alternative statin or statin-based regimen with less potential for the drug-drug interactionPatients that require more than the 40 mg dose should be switched to an alternative drug.

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