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The initial dosage of prednisone may vary from 5 mg to 60 mg per daydepending on the specific disease entity being treatedIn situations of less severity lower doses will generally sufficewhile in selected patients higher initial doses may be requiredThe initial dosage should be maintained or adjusted until a satisfactory response is notedIf after a reasonable period of time there is a lack of satisfactory clinical responseprednisone should be discontinued and the patient transferred to other appropriate therapyIT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENTAfter a favorable response is notedthe proper maintenance dosage should be determined by decreasing the initial drug dosage in small increments at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reachedIt should be kept in mind that constant monitoring is needed in regard to drug dosageIncluded in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease processthe patient’s individual drug responsivenessand the effect of patient exposure to stressful situations not directly related to the disease entity under treatmentin this latter situationit may be necessary to increase the dosage of prednisone for a period of time consistent with the patient’s conditionIf after long-term therapy the drug is to be stoppedit is recommended that it be withdrawn gradually rather than abruptly.

Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.

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