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Read all patient informationmedication guidesand instruction sheets provided to youAsk your doctor or pharmacist if you have any questions.

Generally recognised risk factors for VTE includeuse of estrogensolder agemajor surgeryprolonged immobilisationobesityBody Mass Index30kg/m 2pregnancy/postpartum periodsystemic lupus erythematosusSLEand cancerThere is no consensus about the possible role of varicose veins in VTE.

Take this medication by mouth with or without food as directed by your doctorYou may take it with food or right after a meal to prevent stomach upset.

Combined estrogen-progestogen and estrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic strokeThe relative risk does not change with age or time since menopauseHoweveras the baseline risk of stroke is strongly age-dependentthe overall risk of stroke in women who use HRT will increase with agesee section 4.8

Estrogens may be poorly metabolized in women with impaired liver functionFor women with a history of cholestatic jaundice associated with past estrogen use or with pregnancycaution should be exercisedand in the case of recurrencemedication should be discontinued.

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