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Children weighing more than 45 kg or older than 12 years400 mg orally once a day or 200 mg orally every 12 hours.
SUPRAX tablets and suspensiongiven orallyare about 40to 50absorbed whether administered with or without foodhowevertime to maximal absorption is increased approximately 0.8 hours when administered with foodA single 200 mg tablet of cefixime produces an average peak serum concentration of approximately 2 mcg/mLrange 1 to 4 mcg/mLa single 400 mg tablet produces an average peak concentration of approximately 3.7 mcg/mLrange 1.3 to 7.7 mcg/mLThe oral suspension produces average peak concentrations approximately 25to 50higher than the tabletswhen tested in normal adult volunteersTwo hundred and 400 mg doses of oral suspension produce average peak concentrations of 3 mcg/mLrange 1 to 4.5 mcg/mLand 4.6 mcg/mLrange 1.9 to 7.7 mcg/mLrespectivelywhen tested in normal adult volunteersThe area under the time versus concentration curveAUCis greater by approximately 10to 25with the oral suspension than with the tablet after doses of 100 to 400 mgwhen tested in normal adult volunteersThis increased absorption should be taken into consideration if the oral suspension is to be substituted for the tabletBecause of the lack of bioequivalencetablets should not be substituted for oral suspension in the treatment of otitis mediasee DOSAGE AND ADMINISTRATIONCross-over studies of tablet versus suspension have not been performed in children.
Tonsillitis is a contagious infection with symptoms of bad breathsnoringcongestionheadachehoarsenesslaryngitisand coughing up blood.
400 mg PO once plus azithromycin 1 g PO oncepreferredor alternatively doxycycline 100 mg PO q12hr for 7 days.
SUPRAX is indicated in the treatment of adults and pediatric patients six months of age or older with uncomplicated gonorrheacervical/urethralcaused by susceptible isolates of Neisseria gonorrhoeaepenicillinase-and non-penicillinase-producing isolates
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as a result of the studies, it has been observed that the formulations, in which effervescent couple cefixime ratio is in the range of 15 1 to 3 1, preferably 12 1 to 3 1, more preferably 8 1 to 4 1 , disintegrate rapidly in water and cefixime active agent which has low water solubility dissolves easily in water.