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The dosage is based on your medical condition and response to treatmentTo reduce your risk of side effectssuch as upset stomach and low blood sugaryour doctor may direct you to start this medication at a low dose and gradually increase your doseYour doctor will adjust your dose based on your blood sugar to find the best dose for youFollow your doctor’s instructions carefully.

This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.

Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabeteslowering both basal and postprandial plasma glucoseMetformin hydrochloride decreases hepatic glucose productiondecreases intestinal absorption of glucoseand improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Following administration of a single Glucovance 5 mg/500 mg tablet with either a 20glucose solution or a 20glucose solution with foodthere was no effect of food on the C max and a relatively small effect of food on the AUC of the glyburide componentThe T max for the glyburide component was shortened from 7.5 hours to 2.75 hours with food compared to the same tablet strength administered fasting with a 20glucose solutionThe clinical significance of an earlier T max for glyburide after food is not knownThe effect of food on the pharmacokinetics of the metformin component was indeterminate.

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