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The administration of rizatriptan with other 5-HT 1 agonistse.gsumatriptanzolmitriptannaratriptanhas not been evaluated in migraine patientsBecause their vasospastic effects may be additiveco-administration of rizatriptanand other 5-HT 1 agonists within 24 hours of each other is not recommended.

The primary route of rizatriptan metabolism is via oxidative deamination by monoamine oxidase-AMAO-Ato the indole acetic acid metabolitewhich is not active at the 5-HT 1B1D receptorN-monodesmethyl-rizatriptana metabolite with activity similar to that of parent compound at the 5-HT 1B1D receptoris formed to a minor degreePlasma concentrations of N-monodesmethyl-rizatriptan are approximately 14of those of parent compoundand it is eliminated at a similar rateOther minor metabolitesthe N-oxidethe 6-hydroxy compound and the sulphate conjugate of the 6-hydroxy metabolite are not active at the 5-HT 1B1D receptorNone of these minor metabolites is pharmacologically active.

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The area under the curveAUCof rizatriptan is approximately 30higher in females than in malesThe presence of a migraine headache did not appear to affect the absorption or pharmacokinetics of rizatriptanFood has no significant effect on the bioavailability of rizatriptan but delays the time to reach peak concentration by an hourThe T max is delayed by approximately 1 hour when the tablets are administered in the fed stateIn clinical trialsrizatriptan was administered without regard to food.

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