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Levodopa is a metabolic precursor of dopamine or a compound that participates in the chemical reaction that produces dopaminewhich is able to cross the blood-brain barrier and reach the brainwhere it can be converted to dopamine.

SINEMET helps control some of your symptoms of Parkinson’s diseasebut does not cure itTherefore SINEMET must be taken every dayContinue taking SINEMET for as long as your doctor prescribes.

Safety and effectiveness in pediatric patients have not been establishedUse of the drug in patients below the age of 18 is not recommended.

In the clinical efficacy trials for SINEMETalmost half of the patients were older than 65but few were older than 75No overall meaningful differences in safety or effectiveness were observed between these subjects and younger subjectsbut greater sensitivity of some older individuals to adverse drug reactions such as hallucinations cannot be ruled outThere is no specific dosing recommendation based upon clinical pharmacology data as SINEMET is titrated as tolerated for clinical effect.

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